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July 24, 2026Blood AdvancesOpen Access

Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development

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Authors

JPJoseph A. PidalaBHBetty K. HamiltonGCGeorge Liwei Chen

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Overview

Prospective observational study assesses chronic GVHD incidence and risk factors in transplant survivors, suggesting implications for early therapy trials.

Key Points

  • The study aims to evaluate the incidence, initial presentation, and risk factors for chronic GVHD in transplant survivors.
  • Conducted a prospective, multi-center, observational study across 7 HCT centers.
  • Enrolled 208 subjects and assessed them before and after allogeneic transplantation at specific intervals.
  • Collected clinician assessments, patient-reported measures, and biologic samples at each time point.
  • Cumulative incidence of any chronic GVHD was 54% by 24 months post-HCT.
  • Chronic GVHD requiring systemic immune suppressive therapy occurred in 38% of subjects.
  • Significant associations found between chronic GVHD requiring therapy and baseline donor/recipient CMV positivity, among other factors.

Cite This Study

Pidala et al. (2026) studied this question.

synapsesocial.com/papers/6a630179395161722cd1602fhttps://doi.org/10.1182/bloodadvances.2026021346
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Therapeutic strategies for graft-versus-host disease in the new era].2025
  2. 2Oral chronic graft-versus-host disease (cGVHD) as a potential clinical marker of the graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation: A prospective single-center study2025
  3. 3Clinical trials in graft-versus-host disease: changes in study characteristics, investigated drugs, and endpoints over time2026
  4. 4Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025
  5. 5Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025