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5w ago
Trending on XTop JournalThe Lancet Highlight
Level 2: RCT
Ticagrelor with aspirin dual antiplatelet therapy combined with intravenous thrombolysis in patients with ischaemic stroke in China (TAPIS): a multicentre, double-blind, randomised controlled trial
Early DAPT added to IV thrombolysis improves excellent 90-day functional outcomes ~11% vs placebo.
Implication
Ticagrelor-aspirin DAPT after thrombolysis improves excellent functional outcomes in acute ischaemic stroke; extends dual antiplatelet evidence to this population.
“Early DAPT significantly improved the rate of excellent functional outcome at 90 days (68.7% vs 62.0%; RR 1.11; p=0.0089) without a meaningful increase in symptomatic intracranial haemorrhage, representing an important advance in acute stroke care pending validation in broader populations.”
— Lina PalaiodimouView source
The Lancet
Inserm
6y agoOpen Access
Top JournalEuropean Heart Journal Highlight
Level 2: RCT
Real-world risk of cardiovascular outcomes associated with hypertriglyceridaemia among individuals with atherosclerotic cardiovascular disease and potential eligibility for emerging therapies
Implication
Highlights large eligible population for icosapent ethyl in ASCVD; extends trial criteria to contemporary cohorts.
European Heart Journal
University of Toronto
20w ago
Top Journal
Level 1: Clinical Guideline
Masters athletes with abnormal cardiovascular findings: a clinical consensus statement of the European Association of Preventive Cardiology of the ESC and the American College of Cardiology
Implication
This joint EAPC/ESC and ACC clinical consensus statement provides expert guidance on managing cardiovascular abnormalities in Masters athletes, addressing the limitations of applying standard guidelines to highly trained individuals.
European Heart Journal
Yale University
11w ago
Top Journal
Level 3: Cohort Study
New-onset postoperative atrial fibrillation management and outcomes: the VISION Cardiac Surgery cohort
New-onset postoperative atrial fibrillation occurred in 31.8% of cardiac surgery patients and significantly increased the 1-year risk of all-cause death (aHR 1.54) and clinical AF (aHR 11.30).
Implication
New-onset postoperative atrial fibrillation after cardiac surgery is associated with a significantly increased risk of subsequent clinical AF and all-cause mortality at 1 year, highlighting the need for optimized long-term management.
“One of the goals of these guidelines was not to promote a single dominant therapy, but to provide a structured, phase-based approach that can reduce unwarranted practice variation while still allowing clinical judgment.”
— Subhasis ChatterjeeView source
European Heart Journal
University of Edinburgh
5w ago
Top JournalACC Journal Scan Highlight
Level 2: RCT
Accelerated Diagnostic Pathways for Suspected Acute Coronary Syndrome in Practice
Implication
Randomized trial evaluates accelerated pathways improving diagnostics in acute coronary syndrome.
“The results of MACROS-2 remind us that even when clinical pathways have been validated in rigorous trials, these pathways may not perform as well in some real-world practice setting. Laboratory turnaround times, clinical decision-making and limited resources in clinical practice can challenge eff...”
— ACC Journal ScanView source
Journal of the American College of Cardiology
University of Liverpool
7w ago
Top Journal
Level 1: Meta-Analysis
Optimal serum potassium concentrations in heart failure: an individual patient data meta-analysis
Baseline serum potassium <3.5 mmol/L was associated with a higher risk of all-cause mortality compared to 4.0-4.5 mmol/L in HFrEF (adjusted HR 1.49; 95% CI 1.27-1.76).
Implication
Hypokalemia <3.5 mmol/L flags higher mortality risk in HFrEF; extends RCT-pooled data supporting 4.2-5.0 mmol/L optimization trials.
European Heart Journal
University of Michigan
1w agoOpen Access
Top JournalCirculation Highlight
Level 2: RCT
A Genome-First Study of Familial Hypercholesterolemia Comparing African and European Ancestry Individuals
Implication
Genome-first study compares familial hypercholesterolemia prevalence in African and European ancestry, highlighting different risks.
Circulation
Icahn School of Medicine at Mount Sinai
8w ago
Top JournalNEJM Highlight
Level 2: RCT
Endovascular Therapy for Post-Thrombotic Syndrome — A Randomized Trial
Endovascular therapy led to less severe post-thrombotic syndrome and better quality of life than standard care over 6 months, albeit with a higher bleeding risk.
Implication
Endovascular therapy improves symptoms and quality of life in patients with moderate to severe post-thrombotic syndrome and iliac-vein obstruction at 6 months, though it is associated with an increased risk of bleeding.
“Many patients with PTS suffer in silence because few physicians are aware of this complication or know how to effectively treat it. This study suggests that even severe PTS is, in fact, a treatable condition in many patients.”
— Suresh VedanthamView source
New England Journal of Medicine
Harvard University
5w ago
Top JournalACC Journal Scan Highlight
Level 3: Cohort Study
First Large Comprehensive Core-Laboratory Evaluation of Implantation Depth and Clinical Outcomes in TAVR: Final Global Results from the Optimize PRO Prospective Study
Implication
Prospective study evaluates implantation depth and clinical outcomes in TAVR, suggesting impactful insights for future procedures.
“The proximity of the prosthesis frame to the membranous septum and conduction system has been shown to be strongly depth-dependent, supporting a strategy of higher implantation to minimize mechanical interaction with the atrioventricular conduction tissue.”
— ACC Journal ScanView source
КАРДИОЛОГИЯ УЗБЕКИСТАНА
University of Michigan
5w agoOpen Access
Top JournalACC Journal Scan Highlight
Level 3: Cohort Study
Clinical Outcomes of Transfemoral Transcatheter Mitral Valve Replacement: Results from the CHOICE-MI Registry
Implication
This study evaluates the clinical, echocardiographic, and functional outcomes of transfemoral transcatheter mitral valve replacement in an international registry.
“When placed into the context of early TMVR experiences, which were predominantly performed via a [transapical] access, mortality rates appear favorable. This evolution represents a crucial step forward, offering a definitive valve replacement strategy to a frail, comorbid patient population previ...”
— ACC Journal ScanView source
КАРДИОЛОГИЯ УЗБЕКИСТАНА
University of Toronto