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December 8, 2025Blood

Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis

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Authors

AKAmir KasaeianHAHediyeh AlemiMHMehdi Hamadani

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Overview

Retrospective cohort reveals graft type and donor age impact GVHD in unrelated donor hematopoietic cell transplantation, indicating personalized risk reduction strategies may be beneficial.

Key Points

  • Graft-versus-host disease risk increased with peripheral blood grafts and older donor age, highlighting the importance of graft selection and donor matching.
  • Multivariable logistic regression showed significant odds ratios for acute and chronic GVHD among patients with certain conditions.
  • Retrospective cohort analysis utilized CIBMTR dataset, focusing on adult participants receiving unrelated donor hematopoietic cell transplantation.
  • Findings suggest the need for individualized GVHD risk stratification and tailored prophylactic strategies in treatment.

Cite This Study

Kasaeian et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e225https://doi.org/10.1182/blood-2025-4254
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes after bone marrow versus peripheral blood mismatched unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  2. 2Impact of Conditioning Intensity on Outcomes After Unrelated Donor Hematopoietic Cell Transplantation Using Post-Transplant Cyclophosphamide-Based GVHD Prophylaxis2025
  3. 3Impact of donor age on transplant outcomes in unrelated allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide-based gvhd prophylaxis2025
  4. 4Chronic graft-versus-host disease in the era of post-transplant cyclophosphamide2026 · 5 citations
  5. 5Post-transplant cyclophosphamide-based graft-verses-host disease (GVHD) prophylaxis is associated with a low incidence of fibrotic chronic GVHD after allogeneic hematopoietic cell transplantation across diverse donor types2025