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December 8, 2025BloodOpen Access

Oral chronic graft-versus-host disease (cGVHD) as a potential clinical marker of the graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation: A prospective single-center study

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Authors

NLNicolas LabrueMLMichaël Loschi

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Overview

Prospective study shows oral cGVHD associates with improved overall survival in HSCT patients, suggesting potential as a clinical marker.

Key Points

  • Oral cGVHD significantly improved overall survival and disease-free survival in HSCT patients, indicating possible protective effects.
  • Patients with oral cGVHD had a 72.3% overall survival rate compared to 33% for those without, showing a notable difference in outcomes.
  • Statistical analysis utilized the Cox proportional hazards model to assess the clinical value of oral involvement in cGVHD.
  • These findings highlight the potential for oral cGVHD as a diagnostic tool in optimizing post-transplant management strategies.

Cite This Study

Labrue et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d61dhttps://doi.org/10.1182/blood-2025-7770
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