Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

MPMaria Matthaiakaki PanagiotakiSMShane McCarthyTNThomas Norton

Discussion

Loading...

Member takes

Overview

Longitudinal analysis reveals cytokine responses and immune activation in acute graft-versus-host disease patients receiving corticosteroid treatment, implying potential treatment resistance.

Key Points

  • A significant increase in monocyte-derived dendritic cells is observed in patients with acute graft-versus-host disease during corticosteroid treatment.
  • Clinical remission achieved by 8 out of 10 patients reflects the partial reversion of immune activation markers after corticosteroid treatment.
  • Immunophenotyping of peripheral blood mononuclear cells indicates a persistent activation of CD4+ and CD8+ T cells despite treatment efforts.
  • Elevated levels of Granzyme B and other pro-inflammatory cytokines highlight the ongoing inflammation in treated patients with graft-versus-host disease.

Cite This Study

Panagiotaki et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e200https://doi.org/10.1182/blood-2025-2456
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Peripheral plasmablast expansion as a predictor and therapeutic target in chronic GVHD2025
  2. 2Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study2025
  3. 3Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development2026
  4. 4[Therapeutic strategies for graft-versus-host disease in the new era].2025
  5. 5CSF-1R+ macrophages orchestrate human skin chronic graft-versus-host disease2025