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June 20, 2026Transplantation and Cellular TherapyOpen Access

Clinical trials in graft-versus-host disease: changes in study characteristics, investigated drugs, and endpoints over time

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Authors

PMPhilipp MelhornNDNina DominikLRLina Rüsing

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Overview

Analysis of GvHD trials evaluates design characteristics and treatment trends, indicating a shift toward industry involvement and targeted therapies.

Key Points

  • This analysis aims to characterize treatment trials for graft-versus-host disease registered on ClinicalTrials.gov to identify trends in study features and results.
  • Screened 1,713 records to identify 384 trials meeting inclusion criteria.
  • Characterized phase distribution (15.9% phase 1, 38.8% phase 2, 11.2% phase 3).
  • Evaluated treatment types, designs, and endpoints over the past decade.
  • 61.1% of trials utilized single-group designs and most trials were sponsored by academic institutions (60.4%).
  • The most studied treatments included corticosteroids (64 trials) and mesenchymal stromal cells (52 trials).
  • A significant increase in industry sponsorship from 13.4% to 38.9% (p<0.001) and a shift towards targeted therapies were observed.

Cite This Study

Melhorn et al. (2026) studied this question.

synapsesocial.com/papers/6a36300ddb0793dc1a5375cfhttps://doi.org/10.1016/j.jtct.2026.06.023
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1[Therapeutic strategies for graft-versus-host disease in the new era].2025
  2. 2Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development2026
  3. 3CURRENT PERSPECTIVES ON THE MANAGEMENT OF ACUTE GRAFT-VERSUS-HOST DISEASE IN PEDIATRIC TRANSPLANTATION2025
  4. 4New molecules in the therapy of chronic graft-versus-host disease.2025 · 3 citations
  5. 5Biochemical markers and emerging therapies for intestinal manifestation of graft-versus-host disease2025 · 2 citations