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June 21, 2026Journal of Translational MedicineOpen Access

Glycolytic reprogramming in cancer: tumour cell metabolism, immune modulation, and therapeutic opportunities

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Authors

LWL WangFLFangfang LiuYWYuxuan Wei

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Overview

This review reveals the role of altered glycolysis in tumor metabolism and immune modulation, suggesting new therapeutic strategies.

Key Points

  • This review aims to explore the metabolic reprogramming of cancer cells and its effects on the immune microenvironment.
  • Comprehensive analysis of the relationship between glycolysis and immune cell metabolism.
  • Discussion of potential therapeutic targets within the glycolytic pathway.
  • Assessment of small-molecule inhibitors targeting glycolytic metabolism.
  • Altered glycolytic metabolism enhances tumor cell proliferation and reshapes the tumor microenvironment.
  • Modifications in the tumor microenvironment lead to an imbalanced anti-tumor immune response.
  • Multiple inhibitors targeting glycolytic pathways show promising anti-tumor efficacy in preclinical models.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a377fb224f042ddf4c5a053https://doi.org/10.1186/s12967-026-08418-1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting the glycolytic switch in cancer: mechanisms, cancer progression and therapeutic challenges2025
  2. 2Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours2025
  3. 3Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies2025 · 32 citations
  4. 4Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies2025
  5. 5Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities2025 · 11 citations