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December 6, 2025Chinese Medical JournalOpen Access

Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities

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Authors

WZWenjie Zhu

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Overview

Analysis demonstrates metabolic reprogramming impacts immune responses in tumor microenvironment, suggesting new treatment strategies.

Key Points

  • Tumor microenvironment impairs effector T cells, promoting survival of regulatory T cells.
  • Kynurenine and hypoxia create an immunosuppressive niche limiting antitumor immunity effectiveness.
  • Observational analysis highlights metabolic adaptations of immune cells influencing cancer progression.
  • Targeting metabolic pathways may help enhance therapeutic efficacy and patient outcomes.

Cite This Study

Wenjie Zhu (2025) studied this question.

synapsesocial.com/papers/69337cfbb3f947a0a125a740https://doi.org/10.1097/cm9.0000000000003908
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