Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Clinical and translational reports

Targeting the glycolytic switch in cancer: mechanisms, cancer progression and therapeutic challenges

View Full Paper
Ask AI
Bookmark
Share

Authors

TLTorsten LundbergSLSigurd Lindholm

Discussion

Loading...

Member takes

Overview

This review reveals the mechanisms of the glycolytic switch in cancer and highlights therapeutic challenges in targeting metabolic pathways.

Key Points

  • Glycolytic reprogramming facilitates tumor growth by enhancing ATP production and biomass accumulation.
  • Dysregulated enzymes like HK2 and PKM2 are central to the Warburg effect, affecting glycolytic flux in cancer cells.
  • Lactate from glycolysis alters the tumor microenvironment, promoting immunosuppression and metastasis.
  • Emerging therapies combining glycolytic inhibitors with immunotherapies show potential but face challenges from tumor heterogeneity.

Cite This Study

Lundberg et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64782275https://doi.org/10.58832/ctr.2025.6.6.2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glycolytic reprogramming in cancer: tumour cell metabolism, immune modulation, and therapeutic opportunities2026
  2. 2Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours2025
  3. 3Novel insight into the Warburg effect: Sweet temptation2025
  4. 4Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies2025
  5. 5Deciphering enemy tactics – the narrow path to an optimal anti-cancer strategy targeting the Warburg effect2025