Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 11, 2025Immunology

Molecular Mediators of Metabolic Reprogramming in Cancer: Mechanisms, Regulatory Networks, and Therapeutic Strategies

View Full Paper
Ask AI
Bookmark
Share

Authors

SASana AhujaSZSufian Zaheer

Discussion

Loading...

Member takes

Overview

This review demonstrates the mechanisms of metabolic reprogramming in cancer, highlighting regulatory networks and therapeutic strategies.

Key Points

  • Metabolic reprogramming enables cancer cells to adapt to microenvironmental changes and resist therapies.
  • Central regulators, such as hypoxia-inducible factor-1 and MYC, orchestrate cancer metabolic pathways.
  • Single-cell profiling uncovers intratumoral heterogeneity, revealing complexities in tumor metabolism.
  • Targeting metabolic dependencies presents promising therapeutic opportunities but also significant challenges.

Cite This Study

Ahuja et al. (2025) studied this question.

synapsesocial.com/papers/68e9b1c9ba7d64b6fc132852https://doi.org/10.1111/imm.70045
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanisms, impacts and therapeutic strategies of glucose metabolic reprogramming in tumours2025
  2. 2Metabolic Reprogramming of Cancer Cells and Therapeutics Targeting Cancer Metabolism2025
  3. 3Metabolic Reprogramming: A Crucial Contributor to Anticancer Drug Resistance.2025
  4. 4Metabolic Adaptations in Cancer Progression: Optimization Strategies and Therapeutic Targets2025
  5. 5Targeting the glycolytic switch in cancer: mechanisms, cancer progression and therapeutic challenges2025