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July 23, 2025Experimental Hematology and OncologyOpen Access

Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies

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Authors

RWRuoli WangJZJincheng ZhuangQZQi Zhang

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Overview

This review uncovers how immune cells and tumors interact metabolically, suggesting new immunotherapy strategies to overcome resistance.

Key Points

  • MAIN FINDING: The tumor microenvironment influences immune cell metabolism, impacting treatment responses and resistance.
  • KEY EVIDENCE: Factors like hypoxia and nutrient deprivation drive immune cells toward immunosuppressive states in the TME.
  • APPROACH: The review analyzes metabolic enzymes and cell interactions in the TME, emphasizing recent metabolic innovations.
  • SIGNIFICANCE: Insights into metabolic targeting could enhance immunotherapy effectiveness, addressing current treatment challenges.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdae3https://doi.org/10.1186/s40164-025-00689-6
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Also Consider

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  1. 1Metabolic–immune nexus in tumor microenvironment: From mechanistic insights to therapeutic opportunities2025 · 11 citations
  2. 2Integrating Metabolic Modulation and Nanomedicine for Cancer Immunotherapy.2025 · 15 citations
  3. 3Immunometabolism in the Tumor Microenvironment: Dual Role in Modulating Anti-Tumor Immunity and Tumor Progression2025 · 4 citations
  4. 4Improving Immune Checkpoint Therapy in the Tumor Microenvironment by Targeting T Cell Metabolism2025
  5. 5Deciphering metabolic reprogramming of immune cells within the tumor microenvironment2025 · 10 citations