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January 24, 2026Cardiology in Review

Efficacy and Safety of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Key result

Direct oral anticoagulants reduced all-cause mortality by 62% and VTE recurrence by 83% compared to placebo, with no significant increase in major bleeding.

Authors

MWMuhammad WaqasMAMushtaq AhmedMIMuhammad Ibrahim

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Cite This Study

Waqas et al. (2026) studied this question. Direct oral anticoagulants reduced all-cause mortality by 62% and VTE recurrence by 83% compared to placebo, with no significant increase in major bleeding.

synapsesocial.com/papers/6975661bd5e0d64addde8748https://doi.org/10.1097/crd.0000000000001175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials2025 · 3 citations
  2. 2Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials2025 · 1 citations
  3. 3Reduced-dose versus full-dose direct oral anticoagulants in extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials2025 · 1 citations
  4. 4Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data2025 · 5 citations
  5. 5Three Year Follow-Up of Reduced Dose of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: An Ambispective Cohort Study2025 · 1 citations