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September 12, 2025Thrombosis ResearchOpen Access

Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data

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Authors

AIAhmed IbrahimLSLaila ShalabiSZSofian Zreigh

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Overview

Meta-analysis evaluates efficacy and safety of reduced-dose and full-dose DOACs for VTE, indicating better safety profile for reduced doses.

Key Points

  • Reduced-dose direct oral anticoagulants were as effective as full-dose regimens in preventing recurrent venous thromboembolism.
  • Major bleeding events were significantly lower with reduced-dose DOACs, showing a risk ratio of 0.71 and a confidence interval of 0.61-0.82.
  • Time-to-event data reinforced findings through trial sequential analysis, confirming safety and efficacy outcomes.
  • Subgroup analyses indicated consistency in efficacy and safety across patients with and without active cancer and differing DOAC types.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68d418e1713b0b5dfea64f03https://doi.org/10.1016/j.thromres.2025.109476
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Global Burden of Thrombosis2016 · 1,550 citations