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December 8, 2025Frontiers in PharmacologyOpen Access

Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

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Authors

YLYun LiWCWan Cheng

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Overview

Systematic review finds reduced-dose anticoagulants lower bleeding risk without increasing recurrent VTE in patients.

Key Points

  • This meta-analysis evaluates the clinical benefits of reduced-dose versus full-dose direct oral anticoagulants in extended treatment of venous thromboembolism.
  • Conducted a systematic review and meta-analysis of randomized controlled trials
  • Searched databases including PubMed, Embase, and Web of Science
  • Data extraction performed independently and in duplicate
  • Utilized a random-effects meta-analysis model to report pooled treatment effects and confidence intervals
  • 5 randomized clinical trials included, comprising 8,781 cases
  • Reduced-dose DOACs did not significantly increase risk of recurrent VTE or death
  • Significantly reduced risk of major bleeding/CRNMB with reduced-dose DOACs
  • Apixaban and rivaroxaban showed consistent results for recurrent VTE and major bleeding across subgroups

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/693624984fa91c937236c13dhttps://doi.org/10.3389/fphar.2025.1708316
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials2025 · 3 citations
  2. 2Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data2025 · 5 citations
  3. 3Efficacy and safety of low-dose vs. standard-dose direct oral anticoagulants for secondary prevention of venous thromboembolism: A systematic review and meta-analysis2025
  4. 4Reduced-dose versus full-dose direct oral anticoagulants in extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials2025 · 1 citations
  5. 5Efficacy and Safety of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2026