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September 10, 2025Research and Practice in Thrombosis and HaemostasisOpen Access

Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials

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Authors

MAMushood AhmedEZEeshal ZulfiqarHAHadiah Ashraf

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Overview

Meta-analysis compares efficacy and safety of reduced-dose direct oral anticoagulants and full-dose regimens, indicating significant bleeding risk differences.

Key Points

  • Reduced-dose direct oral anticoagulants effectively prevent recurrent venous thromboembolism and reduce bleeding risks compared to full-dose regimens.
  • The meta-analysis included five randomized controlled trials with a total of 8781 patients, providing robust evidence for dosing strategies.
  • Significant reductions in major and clinically relevant nonmajor bleeding were observed with reduced-dose direct oral anticoagulants.
  • Future research should focus on more randomized controlled trials with extended follow-up, especially in cancer patients, to confirm findings.

Cite This Study

Ahmed et al. (2025) studied this question.

synapsesocial.com/papers/68c2416eb210217d6479f97ahttps://doi.org/10.1016/j.rpth.2025.102996
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