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September 10, 2025Baylor University Medical Center Proceedings

Reduced-dose versus full-dose direct oral anticoagulants in extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials

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Authors

AAAbdullah Faisal AlbukhariYAYazeed AlHarbiMAMeshal M. Alqahtani

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Overview

Systematic review finds reduced-dose direct oral anticoagulants effectively lower recurrence in VTE patients, suggesting a balance with bleeding risks.

Key Points

  • Reduced-dose DOACs significantly prevent recurrence of venous thromboembolism while minimizing bleeding risks.
  • Meta-analysis across randomized controlled trials shows that reduced doses are as effective as full doses for extended treatment.
  • Systematic review process involved analyzing multiple clinical trials to provide evidence-based recommendations for VTE management.
  • Findings suggest that using reduced-dose DOACs may enhance patient safety without compromising efficacy in treating venous thromboembolism.

Cite This Study

Albukhari et al. (2025) studied this question.

synapsesocial.com/papers/68c23b8fb210217d64784e47https://doi.org/10.1080/08998280.2025.2554467
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials2025 · 3 citations
  2. 2Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials2025 · 1 citations
  3. 3Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data2025 · 5 citations
  4. 4Efficacy and Safety of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Systematic Review and Meta-Analysis of Randomized Controlled Trials2026
  5. 5Efficacy and safety of low-dose vs. standard-dose direct oral anticoagulants for secondary prevention of venous thromboembolism: A systematic review and meta-analysis2025