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September 14, 2025DiagnosticsOpen Access

Three Year Follow-Up of Reduced Dose of Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: An Ambispective Cohort Study

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Authors

EVEmanuele ValerianiAPArianna PannunzioTBTommaso Brogi

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Overview

Ambispective cohort study shows low rates of recurrent VTE and bleeding issues in patients treated with reduced dose DOACs.

Key Points

  • Reduced dose of direct oral anticoagulants showed a low rate of recurrent VTE at 0.7% during three years.
  • The study reported a total of four major bleeding incidents, translating to 2.9%, indicating safety in extended treatment.
  • Patients, averaging 72 years old, primarily received apixaban (73.6%) or rivaroxaban (14.3%) over 2.7 years.
  • Assessing cardiovascular risk factors may be crucial due to observed arterial events in this patient population.

Cite This Study

Valeriani et al. (2025) studied this question.

synapsesocial.com/papers/68d42047713b0b5dfea68c2fhttps://doi.org/10.3390/diagnostics15172283
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1PO43 | Extended treatment with reduced dose of direct oral anticoagulants in patients with venous thromboembolism: a retrospective study2025
  2. 2Reduced-Dose Versus Full-Dose Direct Oral Anticoagulants for Extended Treatment of Venous Thromboembolism: A Meta-Analysis of Randomized Controlled Trials2025 · 3 citations
  3. 3Efficacy and safety of low-dose vs. standard-dose direct oral anticoagulants for secondary prevention of venous thromboembolism: A systematic review and meta-analysis2025
  4. 4Full-dose versus reduced-dose comparison of direct oral anticoagulants for extended treatment of venous thromboembolism: a systematic review and meta-analysis of randomized controlled trials2025 · 1 citations
  5. 5Efficacy and safety of reduced-dose versus full-dose direct oral anticoagulants for extended treatment of venous thromboembolism: A meta-analysis with trial sequential analysis and reconstructed time-to-event data2025 · 5 citations