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December 8, 2025BloodOpen Access

Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–2022

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Authors

TOTobechukwu OkobiSJStephen Jesmajian

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Overview

Retrospective cohort analysis shows lower in-hospital mortality in patients with COPD during ACS hospitalization, indicating better resource utilization.

Key Points

  • Patients with chronic obstructive pulmonary disease had a reduction in odds of in-hospital mortality during acute chest syndrome.
  • Study evaluated 36,449 individuals with first-time acute chest syndrome, revealing significant demographic patterns.
  • Analysis based on ICD-10 coding, adjusting for various variables through Charlson Comorbidity Index and statistical measures.
  • Findings highlight the need for continued research into the impacts of coexisting diseases like COPD on important outcomes.

Cite This Study

Okobi et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e209https://doi.org/10.1182/blood-2025-4444
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Also Consider

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  1. 1In-hospital outcomes of patients admitted due to first-time acute chest syndrome with preexisting pulmonary embolism: A nationwide analysis 2016-20222025
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  5. 5Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations