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December 8, 2025BloodOpen Access

In-hospital outcomes of patients admitted due to first-time acute chest syndrome with preexisting pulmonary embolism: A nationwide analysis 2016-2022

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Authors

BLBen LermanAFAlemu FiteVJVera Jokić

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Overview

Retrospective cohort analysis shows increased mortality and resource utilization in acute chest syndrome patients with pulmonary embolism and higher comorbidities.

Key Points

  • Patients with acute chest syndrome and pulmonary embolism had higher mortality rates, along with increased length of hospital stay.
  • Mortality odds increased significantly with higher Charlson comorbidity index scores and older age, showing clear associations.
  • Analysis based on the National Inpatient Sample from 2016-2022 examined inpatient outcomes for specific demographics and conditions.
  • Findings support the need for targeted interventions in patients with sickle cell disease and pulmonary embolism.

Cite This Study

Lerman et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e162https://doi.org/10.1182/blood-2025-1349
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–20222025
  2. 2Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations
  3. 3Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  4. 4Impact of obesity on inpatient outcomes in patients hospitalized with acute chest syndrome2025
  5. 5Regional Variations in the Management and Outcomes of Pulmonary Embolism: A Five‐Year United States Analysis2025