Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis

View Full Paper
Ask AI
Bookmark
Share

Authors

ANAdithya NagendranAVAnushree Venkatesh-MurthyMYMuhammad Yousuf

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows systolic heart failure, atrial fibrillation, and ischemic stroke increase in-hospital mortality in sickle cell disease patients, suggesting urgent intervention needs.

Key Points

  • Significantly increased in-hospital mortality associated with systolic heart failure and atrial fibrillation in sickle cell disease patients, indicating critical health risks.
  • Hypertension and diabetes mellitus also contribute to elevated mortality risk during sickle cell crises, emphasizing the need for monitoring these conditions.
  • Analysis from a large national database identified independent mortality predictors, including Charlson Comorbidity Index assessments for patient profiling.
  • Further investigation is warranted to understand protective mechanisms of chronic coronary artery disease linked to reduced mortality in some cases.

Cite This Study

Nagendran et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d53chttps://doi.org/10.1182/blood-2025-6223
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pulmonary hypertension as an independent predictor of mortality in hospitalized sickle cell disease patients: A national analysis of comorbidities and outcomes2025
  2. 2Analysis of seasonal variation of sickle cell disease with crisis and associated complication in the United States from 2011 to 2019.2025
  3. 3Venous thromboembolism in adults with sickle cell disease: A national inpatient sample analysis (2016–2020)2025
  4. 4Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis2025
  5. 5Trends, Predictors, and Outcomes of Critically Ill Patients With Sickle Cell Disease in the United States2025 · 1 citations