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December 8, 2025BloodOpen Access

Impact of obesity on inpatient outcomes in patients hospitalized with acute chest syndrome

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Authors

AAAbdulmalek AljafariAHAdnan Humam HajjarMPMayank Patel

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Overview

Retrospective analysis reveals obesity increases mechanical and non-invasive ventilation needs in acute chest syndrome patients, suggesting underlying vulnerability.

Key Points

  • Obesity significantly increases the need for mechanical ventilation in patients with acute chest syndrome, highlighting respiratory challenges.
  • Mortality rates were 2.1% for obese patients compared to 1.6% for non-obese, but obesity wasn't linked to higher mortality after adjusting for comorbidities.
  • Analysis of 49,189 ACS hospitalizations utilized National Inpatient Sample data and multivariable logistic regression to assess outcomes.
  • Findings suggest that obesity notably affects respiratory support requirements, prompting calls for targeted interventions in this patient group.

Cite This Study

Aljafari et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dadbhttps://doi.org/10.1182/blood-2025-4727
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Also Consider

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  3. 3Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–20222025
  4. 4Obesity and COVID-19: Pathophysiological Insights and Pulmonary Complications in a Retrospective Cohort Study2025
  5. 5Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025