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December 8, 2025Blood

Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial

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Authors

GAGladstone AireweleNBNitya BakshiDBDavid C. Brousseau

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Overview

Prospective randomized controlled trial shows 20% prevalence of acute chest syndrome in children with sickle cell disease, indicating significant clinical outcomes related to management variations.

Key Points

  • Acute chest syndrome was prevalent in 20% of children hospitalized for vaso-occlusive pain episodes.
  • A total of 271 patients were enrolled, with median age of 15 years and 20% diagnosed with acute chest syndrome.
  • Observational analysis across pediatric emergency departments revealed significant management variations for acute chest syndrome.
  • Standardizing treatment protocols for acute chest syndrome may improve clinical outcomes in sickle cell disease.

Cite This Study

Airewele et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d98dhttps://doi.org/10.1182/blood-2025-2946
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome2025
  2. 2Assessing quality metrics in sickle cell disease: A multicenter review of community hospitals in southwestern Ontario from 2017-2024.2025
  3. 3Secretory phospholipase A2 (sPLA2) during vaso-occlusive pain episodes (VOE) and acute chest syndrome (ACS) in sickle cell disease (SCD): Results from a prospective multi-center randomized controlled trial (RCT)2025 · 1 citations
  4. 4Complement dysregulation during vaso-occlusive episodes can predict development of acute chest syndrome in pediatric patients with sickle cell disease2025
  5. 5Impact of episodes of acute chest syndrom on the cardiac remodeling in children and young adults with sicle cell disease.2025