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December 8, 2025BloodOpen Access

Clinical and laboratory findings in adults with sickle cell disease which increase risk for severe acute chest syndrome

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Authors

JLJason LoftersCCCassandra ChuaBMBharath Miriyam

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Overview

Observational analysis identified low oxygen saturation and high bilirubin as risk factors for severe acute chest syndrome in hospitalized sickle cell disease patients, suggesting need for advanced th

Key Points

  • Severe acute chest syndrome is linked to lower oxygen saturation and higher bilirubin levels, emphasizing their importance for clinicians.
  • 109 patients with acute chest syndrome were analyzed, revealing a significant difference in mortality risk among varying severity grades.
  • This analysis utilized electronic medical records from hospitalizations and confirmed cases through chart review post ICD-10 coding.
  • Findings highlight the necessity for early identification in emergency settings to provide timely interventions like exchange transfusion.

Cite This Study

Lofters et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e49ahttps://doi.org/10.1182/blood-2025-1175
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Application and challenges of the sickle cell outcome grading system (SCOGS) for classifying acute chest syndrome severity2025
  2. 2Revisiting acute chest syndrome (ACS) associated with sickle cell disease (SCD) vaso-occlusive pain episodes (VOE): Insight from a prospective, multicenter Phase-3 randomized controlled trial2025 · 1 citations
  3. 3Acute chest syndrome (ACS) in sickle cell disease (SCD): pathogenesis and pharmacotherapies in early clinical development2025 · 3 citations
  4. 4Rapidly progressive acute chest syndrome is associated with complement-mediated cell injury in adults with sickle cell disease2025
  5. 5Impact of preexisting chronic obstructive pulmonary disease on in-hospital outcomes in first-time acute chest syndrome: A nationwide analysis, 2016–20222025