Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Human intestinal acute graft-versus-host disease is governed by a subset of transition-like tissue-resident memory CD8+ T cells

View Full Paper
Ask AI
Bookmark
Share

Authors

XLXinyu LiuZFZhiping FanRLRen Lin

Discussion

Loading...

Member takes

Overview

Analysis reveals distinct CD8+ T cell subsets in acute graft-versus-host disease, suggesting implications for functional properties and patient outcomes.

Key Points

  • GZMK+ CD8+ T cells dominate the transition-like subset involved in acute graft-versus-host disease.
  • Single-cell RNA sequencing identified significant distinctions among CD8+ T cell subsets in intestinal biopsies from patients.
  • Enhanced infiltration of GZMK+ CD8+ TRMtrans subset is associated with aggravated clinical grades in acute graft-versus-host disease.
  • Insights may lead to targeted therapies addressing the functional properties of distinct T cell subclasses in treatment strategies.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1fbhttps://doi.org/10.1182/blood-2025-2453
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd2025
  2. 2M1 macrophage and Treg crosstalk mapping at single-cell resolution in mucosal chronic graft-versus-host disease 39402025
  3. 3Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025
  4. 4Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025
  5. 5Single-cell RNA sequencing reveals heterogeneity of mucosa-associated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-versus-host disease2025