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November 25, 2025The Journal of ImmunologyOpen Access

M1 macrophage and Treg crosstalk mapping at single-cell resolution in mucosal chronic graft-versus-host disease 3940

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Authors

RSRubina SharmaASAna C. Costa da SilvaNKNoemi Kedei

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Overview

Single-cell RNA sequencing reveals altered M1 macrophage and Treg interactions in mucosal graft-versus-host disease, suggesting altered immune balance.

Key Points

  • This research aims to explore the cellular interactions in chronic graft-versus-host disease (cGVHD), focusing on macrophage and Treg crosstalk.
  • Utilized single-cell RNA sequencing to analyze macrophage subsets in oral mucosa
  • Employed spatial transcriptomics to assess macrophage distribution
  • Conducted spatial proximity analysis to evaluate Treg and M1 macrophage relationships
  • Identified increased M1 macrophage and altered Treg interactions in oral mucosa of cGVHD patients
  • Found significant expression of inflammatory markers such as IL-17 and CD86 in M1 macrophages
  • Revealed decreased presence of TIGIT+ Tregs, indicating disrupted immune homeostasis in cGVHD

Cite This Study

Sharma et al. (2025) studied this question.

synapsesocial.com/papers/692502c987af00ed34ac251ehttps://doi.org/10.1093/jimmun/vkaf283.1682
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