September 10, 2025HaematologicaOpen Access

Single-cell RNA sequencing reveals heterogeneity of mucosa-associated invariant T cells in donor grafts and its diagnostic relevance in gastrointestinal graft-versus-host disease

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Authors

MGMengge GaoPeking University KZKainan ZhangXinjiang Medical University SLSiqi LiCentral South University

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Implication

Single-cell RNA sequencing shows that granulocyte colony-stimulating factor enhances MAIT cell function in preventing gut aGVHD, suggesting new predictive strategies for transplantation outcomes.

Key Points

Granulocyte colony-stimulating factor significantly enhances functional MAIT cells, improving gut aGVHD protection.
The study identifies CXCR6 as critical for MAIT cell migration to gut tissues, impacting transplant outcomes.
Using single-cell RNA sequencing, the research clarifies MAIT cell dynamics in grafts before and after allo-HSCT.
This approach may enable pre-transplant prediction and intervention in gut aGVHD management, potentially changing clinical practices.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68c23e4fb210217d647921fa https://doi.org/10.3324/haematol.2024.287114

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Implication

Single-cell RNA sequencing shows that granulocyte colony-stimulating factor enhances MAIT cell function in preventing gut aGVHD, suggesting new predictive strategies for transplantation outcomes.