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December 8, 2025BloodOpen Access

Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients

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Authors

JPJenny ParedesJKJennifer KarmouchWTWeimin Tsai

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Overview

Pilot trial shows altered microbiome and cytokine levels in patients, suggesting links to graft-versus-host disease incidence.

Key Points

  • Graft-versus-host disease incidence correlates with microbiome features and cytokine profiles after HCT.
  • Levels of pro-inflammatory cytokines IL-6 and others were significantly higher in patients with acute GVHD.
  • Pilot clinical trial assessed microbiome and cytokine profiles after Clostridium butyricum MIYAIRI 588 treatment.
  • Findings highlight potential microbiome-related strategies for mitigating graft-versus-host disease.

Cite This Study

Paredes et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e429https://doi.org/10.1182/blood-2025-6072
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  2. 2Longitudinal and integrated analysis of oral and stool microbiome in allogeneic hematopoietic cell transplantation recipients.2025
  3. 3Poor nutritional intake prior to allogeneic hematopoietic cell transplantation is associated with higher incidence of lower-gastrointestinal graft-versus-host disease2025
  4. 4The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut2025
  5. 5The microbiome in graft-versus-host disease: a tale of two ecosystems2025 · 28 citations