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December 8, 2025Blood

Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd

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Authors

MZMeng ZhangXZXiangjun ZengYLYanjuan Liu

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Overview

Observational analysis found significant thymic dysfunction and systemic inflammation in acute graft-versus-host disease, suggesting new therapeutic strategies may be needed.

Key Points

  • Systemic inflammation was prominent during acute graft-versus-host disease, leading to multi-organ damage.
  • Single-cell RNA sequencing highlighted the aberrant nature of peripheral DP T cells involved in tissue injury.
  • Thymic dysfunction impaired normal negative selection processes, allowing immature T cells to enter circulation.
  • Restoration of thymic function may enable new approaches to mitigate the severity of acute graft-versus-host disease.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df17https://doi.org/10.1182/blood-2025-4240
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025
  2. 2Secondary lymphoid organ endothelial cells prime alloreactive CD4 + T cells to trigger acute graft-versus-host disease2025
  3. 3Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study2025
  4. 4Ornithine decarboxylase deficiency in donor T cells preserves strong GVL activity while attenuating acute and preventing steroid-resistant gut GVHD in a recipient tissue PD-L1-dependent manner2025
  5. 5Human intestinal acute graft-versus-host disease is governed by a subset of transition-like tissue-resident memory CD8+ T cells2025