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December 8, 2025BloodOpen Access

Donor and recipient age-related differences in immunological reconstitution affect development of chronic graft-versus-host disease

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Authors

TNTakaya Nishio

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Overview

Observational analysis uncovers Treg cells significantly influence cGVHD onset in younger patients, indicating donor source impacts reconstitution outcomes.

Key Points

  • Younger patients exhibit improved Treg cell reconstitution at three years after transplantation, enhancing resistance to chronic graft-versus-host disease.
  • Significant differences in Treg cell percentages were observed between young and old patients, highlighting age-related immune responses.
  • Hematopoietic cell transplantation included 81 patients, analyzing variables like donor source and conditioning regimen.
  • Findings suggest immunological reconstitution affects development of chronic graft-versus-host disease, emphasizing age as a crucial factor.

Cite This Study

Takaya Nishio (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236def6https://doi.org/10.1182/blood-2025-4230
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of donor age on transplant outcomes in unrelated allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide-based gvhd prophylaxis2025
  2. 2Older donor age is not associated with inferior survival in contemporary haploidentical transplantation2025
  3. 3Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  4. 4Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study2025
  5. 5Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation2025