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December 8, 2025Blood

Computational dissection of immune reconstitution across diverse conditioning regimens in adults with sickle cell disease undergoing allogeneic stem cell transplantation

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Authors

DGDiane M. GeorgeSPSamuel PanAAAmer Assal

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Overview

Computational analysis shows immune recovery variations in sickle cell disease after allogeneic transplantation, indicating conditioning effects on T-cell and monocyte reconstitution.

Key Points

  • At baseline, sickle cell disease shows a significant B-cell skew compared to healthy controls with 11.6% naïve B-cells.
  • CD34-selected grafts yield the fastest ANC recovery at a median of 19 days versus slower recovery with TBI and PTCy.
  • High-dimensional flow cytometry assesses immune recovery, comparing various conditioning regimens across 70 blood samples.
  • These findings highlight the need for targeted chimerism assays to understand post-transplant immune dynamics in sickle cell disease.

Cite This Study

George et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e239https://doi.org/10.1182/blood-2025-4255
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