Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Impact of donor age on transplant outcomes in unrelated allogeneic hematopoietic stem cell transplantation using post-transplant cyclophosphamide-based gvhd prophylaxis

View Full Paper
Ask AI
Bookmark
Share

Authors

MAMuhammad Kashif AminMSMoazzam ShahzadAZAsma Zakir

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows donor age affects graft-versus-host disease but not overall survival in transplant recipients.

Key Points

  • Donor age did not significantly influence overall survival or non-relapse mortality in transplant recipients.
  • At 3 years, comparable relapse incidence was observed between donor age groups, with 30% noted.
  • Assessment using multivariable Cox proportional hazards models confirmed no adverse effects of older donor age on transplant outcomes.
  • Calls for further research on donor age's role in acute graft-versus-host disease in unrelated donor settings.

Cite This Study

Amin et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfbdhttps://doi.org/10.1182/blood-2025-173
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Older donor age is not associated with inferior survival in contemporary haploidentical transplantation2025
  2. 2Donor Age ≥30 Years as an Independent Predictor of Inferior Outcomes After Haploidentical Hematopoietic Cell Transplantation in Acute Myeloid Leukemia. Study Conducted on Behalf of GETH-TC2025
  3. 3Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC2025 · 1 citations
  4. 4Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  5. 5Impact of conditioning intensity on outcomes after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025