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December 8, 2025Blood

Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study

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Authors

JÁJosé G. Ávila

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Overview

This cohort study examines how graft composition influences aGVHD severity and outcomes in allo-HSCT patients.

Key Points

  • Higher rates of aGVHD were observed, with 44.8% of patients experiencing acute complications.
  • Utilizing a median CD34+ cell dose from peripheral blood showed no significant association with aGVHD severity.
  • Analysis involved flow cytometry to classify T and B lymphocytes in grafts from 29 allo-HSCT patients.
  • The results suggest that understanding graft composition may guide future aGVHD prevention strategies.

Cite This Study

José G. Ávila (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d416https://doi.org/10.1182/blood-2025-7759
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1High donor regulatory B cells (Bregs) and their rapid recovery are associated with protection from the development of acute graft‐versus‐host disease ( aGVHD ) following allogeneic hematopoietic stem cell transplantation2025 · 1 citations
  2. 2Factors associated with acute and chronic graft-versus-host disease after unrelated donor hematopoietic cell transplantation using posttransplant cyclophosphamide-based GVHD prophylaxis2025
  3. 3CD3⁺cell dose is an independent risk factor for grade II–IV aGVHD following cord blood transplantation in children with aplastic anemia2025
  4. 4CD34+/TNC ratio predicts relapse in AML/MDS patients receiving peripheral blood matched allogeneic stem cell transplantation with post-transplant cyclophosphamide2025
  5. 5Donor and recipient age-related differences in immunological reconstitution affect development of chronic graft-versus-host disease2025