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December 8, 2025BloodOpen Access

Older donor age is not associated with inferior survival in contemporary haploidentical transplantation

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Authors

YAYosra AljawaiDMDenái R. MiltonRMRohtesh S. Mehta

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Overview

Analysis shows no major effect of donor age on survival in hematopoietic stem cell transplant, indicating increased graft-versus-host disease risks.

Key Points

  • Overall survival was not significantly affected by older donor age in haploidentical transplantation.
  • Relapse rates were lower for older donors, but they had higher risks of acute graft-versus-host disease.
  • Mortality risk factors included patient age and disease risk index, influencing outcomes significantly.
  • Findings suggest donor age classification remains a limited approach; further exploration of HLA factors is needed.

Cite This Study

Aljawai et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfb3https://doi.org/10.1182/blood-2025-168
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