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December 4, 2025CellsOpen Access

Advanced Glycation End Products Promote PGE2 Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC–NF-κB Pathway

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Authors

MOMisae OnoNTNatsuko TanabeRIRisa Ichikawa

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Overview

Experimental analysis shows AGEs enhance inflammatory mediators and PGE2 in gingival cells, indicating a pathway that may worsen periodontitis in diabetes.

Key Points

  • AGEs promote PGE2 production and COX2 expression in Ca9-22 cells, linking diabetes to increased periodontitis severity.
  • Enhanced inflammatory mediators included COX2 and PGE2 showing significant changes (p < 0.001).
  • Analysis utilized Ca9-22 cells stimulated with AGEs, revealing the involvement of the RAGE/TLR4-mediated pathway.
  • Findings highlight the AGEs impact on inflammation, with potential implications for diabetes-associated periodontitis.

Cite This Study

Ono et al. (2025) studied this question.

synapsesocial.com/papers/6930e8d7ea1aef094cca3a2ahttps://doi.org/10.3390/cells14231911
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Also Consider

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