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September 5, 2025Physiological ResearchOpen Access

AGEs Inducing EPCs Apoptosis via ROS and p38 MAPK/JNK Pathways in Diabetic Vascular Complications

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Authors

XYXiaoli YangZZZhenggang ZhuZLZ Li

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Overview

Experimental analysis shows increased EPC apoptosis in diabetes, suggesting mitigation via antioxidants and MAPK inhibitors.

Key Points

  • AGES trigger EPC apoptosis through oxidative stress, indicating a direct link to vascular damage in diabetes.
  • The analysis showed that apoptosis peaked with high AGES exposure at 24 hours, affecting cell survival.
  • Flow cytometry and Western blot techniques were utilized to measure apoptosis and protein expression in EPCs.
  • This research highlights the potential of antioxidants and specific MAPK inhibitors in preserving EPC function in diabetic conditions.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e6c5https://doi.org/10.33549/physiolres.935554
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