This research reveals AGEs increase pro-inflammatory cytokines in human periodontal ligament fibroblasts, suggesting RAGE/AKT/mTOR involvement in inflammaging.
Key Points
AGEs significantly elevate pro-inflammatory cytokines in response to LPS, linking them to inflammaging.
Inhibiting glycolysis mitigates AGE-induced inflammaging markers, indicating the pathway's vital role in inflammation.
Blocking the AKT/mTOR pathway suppresses AGE-induced inflammaging and glycolysis, highlighting multiple intervention targets.