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September 19, 2025Diabetic Medicine

Advanced glycation end products mediated diabetic neuropathic pain via activation protein tyrosine phosphatase 1B in the spinal cord dorsal horn

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Authors

JWJing WangXLXiaoqin LiRSRuihong Sun

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Overview

Experimental analysis reveals that advanced glycation end products increase pain sensitivity in diabetic models, suggesting implications for pain management strategies.

Key Points

  • Elevated plasma AGEs levels lead to significant hyperalgesia in diabetic neuropathic pain.
  • Specific knockout of PTP1B in the spinal dorsal horn alleviates pain but not anxiety or depression.
  • Electrophysiological recordings indicate that AGEs enhance NMDAR-mediated excitatory currents, mediated by PTP1B.
  • Targeting the AGEs-PTP1B-NMDAR pathway may offer new strategies for diabetes-related pain management.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68d4370d713b0b5dfea770aehttps://doi.org/10.1111/dme.70141
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of MPO/NLRP3 Axis-Mediated Neutrophil Extracellular Traps on Diabetic Neuropathic Pain in a Mouse Model2025
  2. 2The role of rostral ventromedial medulla astrocytes in the pathogenesis and modulation of diabetic neuropathic pain2025
  3. 3RAGE Cytosolic Partner Diaph1 Does Not Play an Essential Role in Diabetic Peripheral Neuropathy Progression2025 · 1 citations
  4. 4Single-cell and experimental analyses identify mitochondria-related genes Hmgcs2, Nudt5, and Cpt1c in painful diabetic peripheral neuropathy2026
  5. 5Preventive effect of RAGE antagonists on distal infraorbital nerve injury-induced pain behaviors of male and female mice2025