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September 10, 2025International Journal of Molecular SciencesOpen Access

The Role of Advanced Glycation End-Products in the Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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Authors

KMKarina Oliveira MotaCVCarla M. L. de VasconcelosZSZhi‐Gang She

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Overview

Observational analysis reveals the link between advanced glycation end-products and cardiovascular disease, indicating new therapeutic targets.

Key Points

  • Elevated advanced glycation end-products are linked to various cardiovascular diseases, leading to oxidative stress and inflammation.
  • AGMA-RAGE interactions contribute to cardiovascular dysfunction by promoting oxidative stress and intracellular calcium overload.
  • Reducing AGE formation and blocking the AGE-RAGE axis shows potential therapeutic benefits in managing cardiovascular diseases.
  • Circulating levels of soluble RAGEs, which provide cytoprotection, vary in cardiovascular disease states, influencing treatment strategies.

Cite This Study

Mota et al. (2025) studied this question.

synapsesocial.com/papers/68c24009b210217d647986c7https://doi.org/10.3390/ijms26157311
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The roles of advanced glycation end products in cardiovascular diseases: from mechanisms to therapeutic strategies2025
  2. 2From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease2025
  3. 3Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review2025
  4. 4Inflammatory Reactions Within the Epicardial Adipose Tissue Are Associated with the Expression of the Receptor for Advanced Glycation End Products in Aortic Stenosis2026
  5. 5Targeting the AGEs-RAGE axis: pathogenic mechanisms and therapeutic interventions in diabetic wound healing2025