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September 18, 2025Frontiers in MedicineOpen Access

Targeting the AGEs-RAGE axis: pathogenic mechanisms and therapeutic interventions in diabetic wound healing

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Authors

HLHaohui LinYYYi YangXWXia Wang

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Overview

This review highlights mechanisms of AGEs-RAGE in diabetic wounds, suggesting therapeutic strategies to enhance healing.

Key Points

  • The AGEs-RAGE axis significantly impairs normal wound healing in diabetes by activating inflammatory pathways.
  • AGEs bind to RAGE, leading to oxidative stress and activation of NF-κB, which hinders vascular function.
  • Emerging therapies like selective RAGE inhibitors and AGE scavengers may enhance treatment for chronic wounds.
  • Chronic non-healing wounds represent a major complication of diabetes, necessitating advanced therapeutic approaches.

Cite This Study

Lin et al. (2025) studied this question.

synapsesocial.com/papers/68d435cf713b0b5dfea74ee1https://doi.org/10.3389/fmed.2025.1667620
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Also Consider

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  1. 1Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review2025 · 13 citations
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  3. 3Resina Draconis Promotes Diabetic Wound Healing by Regulating the AGE-RAGE Pathway to Modulate Macrophage Polarization2025
  4. 4The roles of advanced glycation end products in cardiovascular diseases: from mechanisms to therapeutic strategies2025 · 7 citations
  5. 5From Fork to Brain: The Role of AGE–RAGE Signaling and the Western Diet in Neurodegenerative Disease2025 · 9 citations