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November 28, 2025BMC Oral HealthOpen Access

Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study

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Authors

RURyuta UrakawaYHYuto HorieMOMinako Ohishi

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Overview

Retrospective analysis reveals sulbactam/ampicillin reduces surgical site infections compared to ampicillin, indicating improved antibiotic efficacy.

Key Points

  • Higher surgical site infections observed with ampicillin compared to sulbactam/ampicillin after bimaxillary surgery.
  • SSI incidence in ampicillin group was 46% higher, emphasizing the need for effective prophylactic antibiotics.
  • Retrospective analysis of 115 patients undergoing Le Fort I and bilateral sagittal split osteotomy using four antibiotic regimens.
  • Selecting appropriate antibiotics is crucial for minimizing infection risk following bimaxillary orthognathic surgery.

Cite This Study

Urakawa et al. (2025) studied this question.

synapsesocial.com/papers/6928f113a65b730b9ea79ea5https://doi.org/10.1186/s12903-025-07246-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases.2025
  2. 2Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023
  3. 3Increased Risk of Surgical Site Infections With Clindamycin Prophylaxis in Clean Craniotomy2025
  4. 4Antibiotic Prophylaxis in Instrumented Lumbar Spine Surgery: Cefazolin Outperforms Clindamycin Regardless of Duration2025
  5. 5Extended oral antibiotics fail to reduce surgical site infection in orthopedic surgeries: A comparative study2025