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September 10, 2025PLoS ONEOpen Access

Extended oral antibiotics fail to reduce surgical site infection in orthopedic surgeries: A comparative study

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Authors

AMAlireza MirahmadiPHPooya Hosseini‐MonfaredMFMehrdad Farrokhi

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Overview

Retrospective study compares short-term and extended antibiotics in reducing surgical site infections, indicating that longer use may increase complications.

Key Points

  • Extended oral antibiotics did not reduce surgical site infection rates compared to short-term prophylaxis.
  • Short-term antibiotics had an infection rate of 2.8%, while extended antibiotics had a rate of 4.6% (P = 0.35).
  • Patients receiving extended antibiotics experienced more post-operative complications compared to those on short-term antibiotics.
  • Supportive evidence suggests avoiding extended prophylactic antibiotics beyond 24 hours in orthopedic surgeries.

Cite This Study

Mirahmadi et al. (2025) studied this question.

synapsesocial.com/papers/68c23c20b210217d64788744https://doi.org/10.1371/journal.pone.0330685
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative effectiveness of antibiotic prophylaxis for preventing serious adverse events after primary total hip arthroplasty: a systematic review and network meta-analysis of randomized trials2025
  2. 2Microbial Trends and Risk Analysis of Surgical Site Infections in Various Post-operative Orthopedic Surgeries in a Tertiary Care Teaching Hospital: A Non-interventional Study2025
  3. 3Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study2025
  4. 4Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery2025
  5. 5A comparative study of surgical site infections in clean elective surgical procedures with and without antibiotic prophylaxis2025