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August 16, 2025

Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases.

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Authors

PSPedro SoléPTPablo TapíaSMSebastián Mordoh

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Overview

Retrospective analysis shows cefazolin effectively reduces SSIs in patients undergoing orthognathic surgery, suggesting revised guidelines for antibiotic use.

Key Points

  • Cefazolin significantly reduces the incidence of surgical site infections in orthognathic surgery patients, contrary to clindamycin's effectiveness.
  • Of 100 patients, only 2 with clindamycin prophylaxis developed infections, showcasing the linked risk with this antibiotic in penicillin-allergic individuals.
  • This retrospective study evaluated microbiological data from patients undergoing standardized perioperative care with different antibiotics.
  • Findings emphasize the necessity for updated prophylactic protocols in maxillofacial surgery due to rising microbial resistance.

Cite This Study

Solé et al. (2025) studied this question.

synapsesocial.com/papers/68af2d7ccf1dd9ea359e57f2https://doi.org/10.4317/medoral.27519
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study2025
  2. 2Increased Risk of Surgical Site Infections With Clindamycin Prophylaxis in Clean Craniotomy2025
  3. 3Antibiotic Prophylaxis in Instrumented Lumbar Spine Surgery: Cefazolin Outperforms Clindamycin Regardless of Duration2025 · 2 citations
  4. 4Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023
  5. 5Clinical impact of antibiotic resistance in odontogenic infections: a 12-year analysis of 740 cases2025 · 1 citations