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August 15, 2025AntibioticsOpen Access

Antibiotic Prophylaxis in Instrumented Lumbar Spine Surgery: Cefazolin Outperforms Clindamycin Regardless of Duration

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Authors

ZNZsolt NagyDSDóra SzabóGAGergely Agócs

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Overview

Retrospective analysis reveals cefazolin is more effective in reducing infection rates in instrumented lumbar spine surgery, suggesting optimal antibiotic choice matters.

Key Points

  • Cefazolin significantly reduces surgical site infections compared to clindamycin, with an infection rate of 11.7%.
  • Patients receiving cefazolin showed an odds ratio of 0.45 for infection compared to clindamycin, indicating its superior efficacy.
  • This retrospective analysis involved data from 915 patients who underwent instrumented lumbar spine surgery.
  • Short-term cefazolin use is recommended as it lowers infection risk without increasing resistance or adverse effects.

Cite This Study

Nagy et al. (2025) studied this question.

synapsesocial.com/papers/68af6c0b7567bf4f94fea156https://doi.org/10.3390/antibiotics14080830
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased Risk of Surgical Site Infections With Clindamycin Prophylaxis in Clean Craniotomy2025
  2. 2Recommendation of antibiotic prophylaxis in orthognathic surgery according to current microbial resistance, a retrospective analysis of 100 operated cases.2025
  3. 3Efficacy of Antibiotic Prophlaxis in Preventing Surgical Site Infections: A Review of Current Practices and Emerging Alternatives in General and Plastic Surgery2023
  4. 4Association between prophylactic antibiotics and surgical site infections in bimaxillary orthognathic surgery: a retrospective study2025
  5. 5Timing of antibacterial prophylaxis and surgical site infection rates in clean orthopaedic and cardiac surgery2025