Retrospective analysis shows clindamycin significantly raises surgical site infection risk in craniotomy patients, highlighting the need for optimal antibiotic prophylaxis.
Key Points
Clindamycin administration increased surgical site infections in patients after clean craniotomy, suggesting a need for reevaluation of prophylactic protocols.
The adjusted odds ratio for surgical site infections with clindamycin was 2.52, indicating a substantial risk compared to cefazolin.
Propensity score matching analysis revealed clindamycin's association with higher infection rates and indicated 90-day revision risk for infection at an odds ratio of 2.09.
Independent risk factors included male sex, prolonged surgery, and cerebrospinal fluid leakage, the strongest predictor with an aOR of 38.51.