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November 28, 2025Translational PsychiatryOpen Access

Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study

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Authors

GLGail LeeKWKarina WilkCCCheryl Chong

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Overview

Longitudinal mouse MRI demonstrates brain development changes linked to maternal diet, indicating increased risks for neurodevelopmental disorders.

Key Points

  • Offspring brain development exhibited significant changes due to maternal obesity and diabetes, impacting key structures.
  • Key brain structures involved include the cingulate cortex and hippocampus, associated with memory and social cognition.
  • Longitudinal MRI tracking showed changes during gestation, lactation, and into adulthood despite dietary shifts.
  • Study findings underscore the need for interventions to address neurodevelopmental disorders related to maternal diet.

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/6928f0f9a65b730b9ea79895https://doi.org/10.1038/s41398-025-03701-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neurodevelopmental effects of parental high fat/high sugar diets assessed by structural MRI in a mouse model2025
  2. 2Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice2025
  3. 3Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism2025
  4. 4Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice2025
  5. 5Structural and Functional Brain Changes in Children and Adolescents With Obesity2025 · 8 citations