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September 17, 2025Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

Neurodevelopmental effects of parental high fat/high sugar diets assessed by structural MRI in a mouse model

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Authors

EME. McKnightGLGail LeeKWKatarzyna Wilk

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Overview

Analysis reveals high fat and sugar diets alter brain structure in mice, implying risks for neurodevelopmental disorders.

Key Points

  • Diets high in fat altered brain volume, while diets high in sugar only did not produce significant changes.
  • Structural MRI was used to evaluate changes in brain regions in young adult mice after parental high fat or combined diets.
  • This study shows early dietary interventions may have lasting neurodevelopmental impacts, indicating potential human implications.
  • Findings suggest the need for careful dietary considerations during pregnancy to mitigate risks of neurodevelopmental disorders.

Cite This Study

McKnight et al. (2025) studied this question.

synapsesocial.com/papers/68d4293e713b0b5dfea6ef3dhttps://doi.org/10.58530/2025/3647
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study2025
  2. 2Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice2025
  3. 3Fat sensory cues in early life program central response to food and obesity2025
  4. 4Prenatal fructose exposure independently impacts placental phenotype and female offspring kidney function and liver composition in rats2025
  5. 5Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice2025