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August 19, 2025Translational PsychiatryOpen Access

Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism

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Authors

KCKuan-Ru ChenYHYu-Cheng HoCHChih‐Wei Huang

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Overview

Observational analysis shows impaired cognition and memory in offspring due to prenatal high-fat diet exposure, indicating NMDA receptor involvement.

Key Points

  • Maternal high-fat diet exposure in utero impairs spatial memory and cognition in offspring, causing behavioral abnormalities.
  • Key evidence indicates that hippocampal NMDA receptor expression is reduced, linked to deficits in learning and memory.
  • Investigation conducted using controlled diet conditions during lactation for offspring reared by foster mothers.
  • These findings suggest that alterations in NMDA receptor signaling may contribute to neurodevelopmental risks associated with maternal obesity.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af31ddcf1dd9ea359e7a10https://doi.org/10.1038/s41398-025-03520-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice2025
  2. 2Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice2025
  3. 3Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study2025
  4. 4Interruption of the Gut Integrity Contributes to Early Accumulation of Amyloid-β in the Enteric Nervous System in Rats Supplemented with a High-Fat Diet2025
  5. 5Altered Hippocampal Transcriptomic Profile Reveals Cognitive Impairment in Young Metabolically Obese, Normal‐Weight Rats, Prevented by Perinatal Leptin Intake2025