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September 10, 2025Translational PsychiatryOpen Access

Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice

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Authors

CMChiara MusilloMSMaria Teresa SamàKCKerstin Camile Creutzberg

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Overview

Observational analysis shows prenatal N-acetyl-cysteine prevents cognitive impairments in offspring, indicating potential protective mechanisms against maternal high-fat diets.

Key Points

  • Prenatal N-acetyl-cysteine prevented anxiety-like behaviors and cognitive impairments in adult mouse offspring.
  • Results highlighted significant downregulation of BDNF in response to maternal high-fat diet exposure.
  • Approach included assessments of behavioral, metabolic, and gene expression responses in a mouse model.
  • Findings suggest rebalancing redox status may buffer negative effects of early adverse experiences.

Cite This Study

Musillo et al. (2025) studied this question.

synapsesocial.com/papers/68c24317b210217d647a5299https://doi.org/10.1038/s41398-025-03530-0
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