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September 10, 2025Aging CellOpen Access

Peri‐ and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice

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Authors

LCLaura ContuAJAdam JohnsonCHChristopher J. Heath

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Overview

This study demonstrates the effects of high fat diet on executive function in C57BL/6J mice, indicating potential benefits of perinatal feeding.

Key Points

  • At 12 months old, postnatal high fat feeding improved cognitive performance in male mice, while early high fat feeding had mixed effects.
  • C/HF and HF/HF mice displayed significantly poorer executive function compared to C/C and HF/C at 6 months, indicating the negative impact of high fat feeding.
  • Markers of acetylcholine and NeuN were increased in the prefrontal cortex of HF/C animals, revealing a potential neurobiological mechanism for observed changes.
  • These results suggest a complex interaction between diet type during different life stages and cognitive outcomes, highlighting the importance of early dietary choices.

Cite This Study

Contu et al. (2025) studied this question.

synapsesocial.com/papers/68c23d81b210217d6478dd2fhttps://doi.org/10.1111/acel.70223
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study2025
  2. 2Prenatal maternal HFD exposure impairs cognition via a hippocampal NMDA mechanism2025
  3. 3Sex-dependent preventive effects of prenatal N-acetyl-cysteine on neuronal, emotional and metabolic dysfunctions following exposure to maternal high-fat diet in mice2025
  4. 4High-Fat Diet Alters Behavior and Hippocampal Gene Expression2025
  5. 5Postnatal High-Fat Diet Consumption by Male Rat Offspring of Obese Mothers Accentuates Negative Outcomes of Reproductive Function in Young Adults2025