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August 5, 2025Obesity ReviewsOpen Access

Structural and Functional Brain Changes in Children and Adolescents With Obesity

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Authors

SZSixiu ZhaoLSLorenzo SemeiaRVRalf Veit

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Overview

Review highlights alterations in brain structure and function in pediatric obesity, pointing to implications for interventions.

Key Points

  • Pediatric obesity negatively affects brain structure and function, particularly in limbic regions.
  • MRI studies reveal that these changes depend on developmental stages of children and adolescents.
  • Interventions, including exercise and behavioral changes, show promise in improving brain outcomes in affected youths.
  • Changes in brain activation patterns during decision-making are linked to higher body mass index, highlighting significant implications for treatment.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/689a0f93e6551bb0af8d1114https://doi.org/10.1111/obr.70001
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of obesity on human brain metabolites: a systematic review on magnetic resonance spectroscopy studies2025
  2. 2Multimodal Neuroimaging of Brain Structure, Metabolism, and Function in Obesity: Current Landscape and Future Perspectives2025
  3. 3Parental high-fat/high-sugar diets and their lasting impact on brain development in offspring: a longitudinal mouse MRI study2025
  4. 4Neuroanatomical Reflections of Childhood Obesity: Volumetric Analysis of the Pituitary Gland and Olfactory Bulb2025
  5. 5Neurodevelopmental Pathways from Maternal Obesity to Offspring Outcomes: An Umbrella Review of Cognitive and Behavioral Consequences Across Development2025